| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367474 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Synthesis of chiral spirocyclic helical compounds containing leucine that mimic the core of DNA bulge binder NCSi-gb has been described. The interaction between the compounds and DNA was studied by circular dichroism (CD). The results suggested that the two synthetic diastereoisomers 7 and 8 specifically targeted the bulge site of DNA and induced conformational change of bulged DNA greatly.
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Authors
Zhen Xi, Di Ouyang, Hong-Tao Mu,