| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367476 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of 4,4-disubstituted cyclohexylamine NK1 antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model.
Graphical abstractThe discovery of potent NK1 antagonists such as 8a is reported. Compound 8a displays good activity in a ferret emesis model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gregory J. Hollingworth, Emma J. Carlson, José L. Castro, Gary G. Chicchi, Natalie Clark, Laura C. Cooper, Olivier Dirat, Jerry Di Salvo, Jason M. Elliott, Ruth Kilburn, Marc M. Kurtz, Wayne Rycroft, F. David Tattersall, Kwei-Lan Tsao,