| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367480 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Fully flexible docking of KT5720, an allosteric modulator of the muscarinic receptors, was performed on a dynamic model of the M1 muscarinic acetylcholine receptor. The results confirmed the existence of a second allosteric site, located on the intracellular face of the receptor. These results would be beneficial for the design of modulators of this receptor to be used as an effective alternative against the Alzheimer's disease.
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Authors
L. Michel Espinoza-Fonseca, José G. Trujillo-Ferrara,