Heteropoly acids as solid green Brønsted acids for a one-pot synthesis of β-acetamido ketones by Dakin–West reaction

An efficient improved procedure for the synthesis of β-acetamido ketones has been developed by a heteropoly acid (HPA) catalyzed three-component coupling protocol. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times, and mild conditions.

Graphical abstractA new and important catalytic activity of HPAs (cheap, commercially available, noncorrosive, and environmentally benign compounds) has been studied for the synthesis of β-acetamido ketones in excellent yields under mild reaction conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide