Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367486 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Antimicrobial peptides and their mimetics offer a potential new disinfective tool. β-Peptoids (oligo-N-substituted β-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-β-peptoids were first prepared and then ligated via amide bond formation to synthesize larger β-peptoids was developed. The β-peptoids were found to possess moderate activity in an Escheridchia coli assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven W. Shuey, William J. Delaney, Mukesh C. Shah, Mark A. Scialdone,