| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367493 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Two series of simplified analogs of the ecteinascidin–saframycin type alkaloids were prepared from l-DOPA. Their in vitro antitumor activity was tested against three human cancer cell lines (HCT-8 colon carcinoma, Bel-7402 liver carcinoma, and BGC-823 gastric carcinoma). Among these compounds, the ester analogs have stronger activities than those of amide analogs in general. Among them, 1-naphthalene carboxylate ester analog 31 has the strongest activity against BGC-823 cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhan-Zhu Liu, Ye Wang, Ye-Feng Tang, Shi-Zhi Chen, Xiao-Guang Chen, Hong-Yan Li,