SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

A novel series of 5-aminopyrimidinyl quinazolines has been developed from anilino-quinazoline 1, which was identified in a high throughput screen for Aurora A. Introduction of the pyrimidine ring and optimisation of the substituents both on this ring and at the C7 position of the quinazoline led to the discovery of compounds that are highly specific Aurora kinase inhibitors. Co-crystallisation of one of these inhibitors with a fragment of Aurora A shows the importance of the benzamido group in achieving selectivity.

Graphical abstractThe discovery, optimisation and subsequent structural determination of a novel class of Aurora kinase inhibitors are described.Figure optionsDownload full-size imageDownload as PowerPoint slide