Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

The design, synthesis, and structure–activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described.

Graphical abstractThe synthesis and structure–activity relationship of two new classes of benzoxazines with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described.Figure optionsDownload full-size imageDownload as PowerPoint slide