| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367508 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.
Graphical abstractanti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-4 inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound 9 exhibited good pharmacokinetic profiles in three preclinical species.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jinyou Xu, Lan Wei, Robert Mathvink, Scott D. Edmondson, Anthony Mastracchio, George J. Eiermann, Huaibing He, Joseph F. Leone, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Aleksandr Petrov, Joseph K. Wu, Nancy A. Thornberry,