| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367513 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
6-Chloro-2-pyrrolidino-/morpholino-/piperidino-/N-methylpiperazino-3-formyl-chromones (13–16) and 6-fluoro-2,7-di-morpholino-/piperidino-/N-methylpiperazino-3-formylchromones (17–19) have been synthesized as potential topoisomerase inhibitor anticancer agents, and evaluated, in vitro, against Ehrlich ascites carcinoma (EAC) cells, and also in vivo on EAC bearing mice. The compounds displayed promising anticancer activity under these test systems and shall serve as useful ‘leads’ for further design.
Graphical abstractNovel chromone derivatives have been developed as potential DNA-topoisomerase inhibitors, which have displayed promising anticancer activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.P.S. Ishar, Gurpinder Singh, Satyajit Singh, K.K. Sreenivasan, Gurmit Singh,