Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution

Article ID	Journal	Published Year	Pages	File Type
1367514	Bioorganic & Medicinal Chemistry Letters	2006	9 Pages	PDF

Abstract

We identified new lead candidates which showed potent dual inhibition against phosphodiesterase-1 and 5 by a ligand-based virtual screening optimized for lead evolution. The obtained lead candidates were structurally diverse.

Keywords

CART PDE-5 Virtual screening Pharmacophore Phosphodiesterase Dual inhibitors

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution

Authors

Kazuto Yamazaki, Naoto Kusunose, Katsuya Fujita, Hideshi Sato, Shigehiro Asano, Akihito Dan, Masaharu Kanaoka,