| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367518 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sergio A. Alonso De Diego, Marta Gutiérrez-Rodríguez, M. Jesús Pérez de Vega, Diego Casabona, Carlos Cativiela, Rosario González-Muñiz, Rosario Herranz, Edurne Cenarruzabeitia, Diana Frechilla, Joaquín Del Río, M. Luisa Jimeno, M. Teresa García-López,