| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367522 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis of triplexes possessing an anthraquinonyl group and composed of branched oligonucleotides (ONs) is described. Binding ability of a triplex-binding protein (MBP-LOR3ARF) to the triplexes was evaluated by an electrophoretic mobility shift assay (EMSA). It was found that the triplex, which has an anthraquinonecarbonyl group at the 5′-end of the third strand and is connected with the pentaerythritol linker, has greater affinity to the protein than an unmodified triplex.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aya Shibata, Yoshihito Ueno, Koichiro Shinbo, Masayuki Nakanishi, Akira Matsuda, Yukio Kitade,