| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367610 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC50 value and high level of selectivity over other recombinant phosphatases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Sung Yun Cho, Ji Yoen Baek, Sang Sub Han, Seung Kyu Kang, Jae Du Ha, Jin Hee Ahn, Jae Don Lee, Kwang Rok Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Sung Don Yang, Gyu Hwan Yon, Chwang Siek Pak, Joong-Kwon Choi,