| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367612 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Compounds 8 and 41 are potent analogs of farnesyltransferase inhibitors that were identified from an ECLiPS® library screen. X-ray crystallographic analyses of inhibited complexes show that the side-chain pyridyl of 8 and the imidazoyl of 41 coordinate to the active site zinc.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chia-Yu Huang, Tara M. Stauffer, Corey L. Strickland, John C. Reader, He Huang, Ge Li, Alan B. Cooper, Ronald J. Doll, Ashit K. Ganguly, John J. Baldwin, Laura L. Rokosz,