| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367615 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Fragment-based virtual library design and virtual screening have been conducted against malic enzyme (ME) homology model. Several scaffolds have been identified as promising motifs to target ME’s NADP binding site. One small focused library has been synthesized and tested against ME. Several compounds from this library have shown sub-micromolar inhibitory activity against malic enzyme.
Graphical abstractFragment-based virtual library design and virtual screening have been conducted against malic enzyme (ME) homology model. Compounds from this library have shown submicromolar inhibitory activity against malic enzyme.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Y. John Zhang, Zhaolin Wang, Dennis Sprous, Roustem Nabioullin,