| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367617 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A variety of gem-diamine 1-N-iminosugars related to l-iduronic acid were synthesized and evaluated as inhibitors of heparan sulfate uronyl 2-O-sulfotransferase using an in vitro enzyme assay. Two iminosugars containing guanidino groups acted as potent in vitro inhibitors of the enzyme.
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Authors
Jillian R. Brown, Yoshio Nishimura, Jeffrey D. Esko,