| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367618 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis of a small collection of sulfamoyl-4-oxoquinoline-3-carboxamides is described for use as correctors of defective gating of the ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Several compounds with submicromolar potency were obtained. N-Ethyl 6-(ethylphenylsulfamoyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (7b) was found to be the most effective sulfonamide corrector of defective ΔF508-CFTR gating.
Graphical abstractEvaluation and synthesis of sulfamoyl-4-oxoquinoline-3-carboxamide correctors of defective gating of the ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yat Fan Suen, Lori Robins, Baoxue Yang, A.S. Verkman, Michael H. Nantz, Mark J. Kurth,