| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367624 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.
Graphical abstractOxime ether formation at C-9 carbonyl and methylation at C-6 hydroxy group of erythromycin A followed by transformation to ketolides gave the derivative II, which exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ghilsoo Nam, Tae Won Kang, Jung Hyu Shin, Kyung Il Choi,