| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367631 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Novel potent derivatives of 4-(azolylethyl)thiazole-5-carboxamides are described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity reaching IC50Â <Â 100Â nM in both enzymatic and cell-based phosphorylation assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1, with similar potencies.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexander S. Kiselyov, Evgueni Piatnitski, Marina Semenova, Victor V. Semenov,