Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367634 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (i.e., sGC activation) of photolabile analogues of 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When photoactivated, this analogue labeled the α-subunit of sGC.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kirk W. Hering, Jennifer D. Artz, William H. Pearson, Michael A. Marletta,