| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367636 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.
Graphical abstractThe synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhong Chen, Soong-Hoon Kim, Stephanie A. Barbosa, Tram Huynh, David R. Tortolani, Kenneth J. Leavitt, Donna D. Wei, Veeraswamy Manne, Carolyn S. Ricca, Johnni Gullo-Brown, Michael A. Poss, Wayne Vaccaro, Mark E. Salvati,