| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367638 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the β-secretase inhibitor 7m which has an in vitro IC50 = 35 nM. The synthesis and biological activities of these compounds are described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Min-Chi Crouthamel, Beth L. Pietrak, Ming-Tain Lai, M. Katharine Holloway, Sanjeev K. Munshi, Samuel L. Graham, Joseph P. Vacca,