| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367644 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het–NH–Ph–U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het = 2-thiazoyl and 2-pyrimidinyl are the focus of this report.
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Authors
Juliana Ruiz-Caro, Aravind Basavapathruni, Joseph T. Kim, Christopher M. Bailey, Ligong Wang, Karen S. Anderson, Andrew D. Hamilton, William L. Jorgensen,