| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367646 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT2 receptor subtypes are reported. The analogue which showed the highest 5-HT2C binding affinity (27, 1.6 nM) was found to be successful in reducing food intake in rats.
Graphical abstractA series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was prepared and evaluated as 5-HT2C receptor agonists for the treatment of obesity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David R. Adams, Jonathan M. Bentley, Karen R. Benwell, Michael J. Bickerdike, Corinna D. Bodkin, Ian A. Cliffe, Colin T. Dourish, Ashley R. George, Guy A. Kennett, Antony R. Knight, Craig S. Malcolm, Howard L. Mansell, Anil Misra, Kathleen Quirk,