| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367648 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ji-Feng Liu, Christopher J. Wilson, Ping Ye, Kevin Sprague, Katie Sargent, Ying Si, Galina Beletsky, Daniel Yohannes, Shi-Chung Ng,