| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367661 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The SAR of the lead compound 3, a novel ligand for the α2δ subunit of voltage-gated calcium channels, was rapidly explored. Utilizing a parallel solution-phase Sn2Ar coupling approach, a focused library was obtained. The library was evaluated in vitro and afforded a series of analogues with improved potencies. The SAR trends of the library are also described.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chixu Chen, Brian Stearns, Tao Hu, Naomi Anker, Angelina Santini, Jeannie M. Arruda, Brian T. Campbell, Purabi Datta, Jayashree Aiyar, Benitio Munoz,