Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367701 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The concept of bivalent polypeptides with controllable flexible linkers is demonstrated through the design of a new generation of ‘antidote’-reversible inhibitors of thrombin. These molecules contain two binding moieties, each of which in isolation has only a moderate affinity of binding, which are linked together by a flexible peptide bridge. We show that activities of the potent bivalent inhibitors of thrombin can be reversed by the specific, but much weaker, binding of the linker moiety to protein ‘antidotes’.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dmitri Tolkatchev, Anna Vinogradova, Feng Ni,