| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367706 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Inhibitors of mammalian ribonucleotide reductase possessing a novel octahydropyranopyrrole scaffold based on a cyclic heptapeptide inhibitor have been designed, synthesized, and evaluated. Structure-function studies reveal that the bicyclic scaffold is indeed necessary to maintain inhibitory activity.
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Authors
Michael J. Fuertes, Jaskiran Kaur, Prasant Deb, Barry S. Cooperman, Amos B. III,