Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367707 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
In an effort to prepare novel inhibitors of bacterial aminopeptidase N (PepN), the phosphinate, propenylphosphinate, decylphosphinate, sulfonate, and sulfonamidate analogs of Ala–Ala were synthesized and tested as inhibitors. Phosphinate 1 was shown to inhibit PepN with a Ki of 10 μM, and propenylphosphinate 2 and decylphosphinate 3 inhibited PepN with a Ki of ca. 1 μM. Sulfonate and sulfonamidate analogs did not inhibit PepN.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ke-Wu Yang, Frank C. Golich, Tara K. Sigdel, Michael W. Crowder,