| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367717 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.
Graphical abstractA series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoyan Zhang, Maud Urbanski, Mona Patel, Roxanne E. Zeck, Geoffrey G. Cox, Haiyan Bian, Bruce R. Conway, Mary Pat Beavers, Philip J. Rybczynski, Keith T. Demarest,