| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367729 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.
Graphical abstractWe report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Curt D. Haffner, Darryl L. McDougald, Steven M. Reister, Brian D. Thompson, Christopher Conlee, Jing Fang, Jonathan Bass, James M. Lenhard, Dallas Croom, Melissa B. Secosky-Chang, Thaddeus Tomaszek, Donavon McConn, Kevin Wells-Knecht, Paul R. Johnson,