| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367736 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The synthesis and structure–activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lori Krim Gavrin, Neal Green, Yonghan Hu, Kristin Janz, Neelu Kaila, Huan-Qiu Li, Steve Y. Tam, Jennifer R. Thomason, Ariamala Gopalsamy, Greg Ciszewski, John W. Cuozzo, J. Perry Hall, Sang Hsu, Jean-Baptiste Telliez, Lih-Ling Lin,