| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367738 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Indoles 11 and 12 (R1 and/or R2Â =Â NHCH3 or H; R and R3Â =Â NH2 or H) were examined to determine the influence of amine substituents on 5-HT6 receptor affinity. Although all compounds displayed low nanomolar affinity, only a single aryl amine moiety is required for binding. It appears that multiple modes of binding are possible upon interaction of these types of compounds with 5-HT6 receptors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manik Pullagurla, Uma Siripurapu, Renata Kolanos, Mikhail L. Bondarev, MaÅgorzata Dukat, V. Setola, B.L. Roth, Richard A. Glennon,