| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367743 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory potency and affinity for the α2-adrenoceptor. Although their PNMT inhibitory potency decreased compared with corresponding 3-methyl-, 3-hydroxymethyl- or 3-unsubstituted-THIQs, some of them showed good selectivity due to their extremely low α2-adrenoceptor affinity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gary L. Grunewald, Jian Lu, Kevin R. Criscione, Cosmas O. Okoro,