| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367748 | Bioorganic & Medicinal Chemistry Letters | 2005 | 9 Pages |
Abstract
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
Graphical abstractWe describe the structure-based design and synthesis of nanomolar, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Katrin Groebke Zbinden, Ulrike Obst-Sander, Kurt Hilpert, Holger Kühne, David W. Banner, Hans-Joachim Böhm, Martin Stahl, Jean Ackermann, Leo Alig, Lutz Weber, Hans Peter Wessel, Markus A. Riederer, Thomas B. Tschopp, Thierry Lavé,