Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367830 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
Graphical abstractA novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones has been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed, which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christopher D. Beadle, John Boot, Nicholas P. Camp, Nancy Dezutter, Jeremy Findlay, Lorna Hayhurst, John J. Masters, Roberta Penariol, Magnus W. Walter,