| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367836 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at α4β2* and α7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guangrong Zheng, Linda P. Dwoskin, Agripina G. Deaciuc, Peter A. Crooks,