| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367839 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The 17-membered phenylalanine-based macrocycle 6 was prepared starting from 3-iodo-phenylalanine. Macrocyclization of alkene phenyl iodide 5 was effected through a palladium-catalyzed Heck reaction. The macrocyclic α-ketoamides were active inhibitors of the HCV NS3 protease, with the C-terminal acids and amides being more potent than tert-butyl esters.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kevin X. Chen, F. George Njoroge, Andrew Prongay, John Pichardo, Vincent Madison, Viyyoor Girijavallabhan,