| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367840 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Two-arm branched mPEG (monomethoxy-polyethylene glycol) with different molecular weights (Mn = 4000, 6000, 9400) was synthesized and used as carrier for immobilization of cisplatin [cis-diammine(dichloro)platinum (II), CDDP]. As a contrast, CDDP modified with linear mPEGs was also synthesized. All these polymeric drugs modified with branched mPEG are water soluble and show higher cytotoxic activity against C6 human breast cancer cells than cisplatin modified with linear mPEG with the same molecular weight. All the polymeric CDDP showed a much lower toxicity than the CDDP.
Graphical abstractTwo-arm branched mPEG was synthesized and used as carrier for immobilization of CDDP.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong Ren, Haitao Zhang, Junlian Huang,