| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367847 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A new AChE tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium ([11C]MDDP, [11C]1) has been synthesized in 40-65% radiochemical yield. Initial PET dynamic studies of [11C]MDDP in rat heart showed rapid heart uptake and blood pool clearance to give high-quality heart images. Blocking studies of [11C]MDDP with pretreatment drug neostigmine in rats found only minor reductions in rat heart [11C]MDDP retention. The results suggest that [11C]MDDP delineates the heart very clearly, and the uptakes of [11C]MDDP in rat heart might be related to non-specific binding.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium](/preview/png/1367847.png "First Page Preview: Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium")
Authors
Ji-Quan Wang, Michael A. Miller, Bruce H. Mock, John C. Lopshire, William J. Groh, Douglas P. Zipes, Gary D. Hutchins, Qi-Huang Zheng,