Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367848 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Modification of the P2 and P1 side chains of earlier P3-capped α-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency.
Graphical abstractModification of the P2 and P1 side chains of earlier P3-capped α-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
S. Bogen, A.K. Saksena, A. Arasappan, H. Gu, F.G. Njoroge, V. Girijavallabhan, J. Pichardo, N. Butkiewicz, A. Prongay, V. Madison,