| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367851 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Reporter cell lines are often used for high-throughput screening of natural product libraries or chemical libraries to identify new receptor ligands. Screening of neuromedin U2 receptor (NMU2R) ligands may be very useful to treat obesity for the reason that centrally administered neuromedin U affects feeding behavior, energy expenditure, and pituitary. Here, we have developed a stable cell line of neuromedin U2 receptor (NMU2R) to screen for its agonist. The experimental results demonstrate that icariin, isolated from Herba epimedii, was a strong agonist for NMU2R, which could selectively activate NMU2R, but not M1R, MC4R, and negative cell lines.
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Related Topics
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Authors
Xuxu Zheng, Yinghe Hu, Jianhui Liu, Keqing Ouyang,