| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367864 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Structure–activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter C. Chua, Johnny Y. Nagasawa, Leo S. Bleicher, Benito Munoz, Edwin J. Schweiger, Lida Tehrani, Jeffrey J. Anderson, Merryl Cramer, Janice Chung, Mitchell D. Green, Chris D. King, Grace Reyes-Manalo, Nicholas D.P. Cosford,