| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367873 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity.
Graphical abstractA series of substituted pyrazoline were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fedele Manna, Franco Chimenti, Rossella Fioravanti, Adriana Bolasco, Daniela Secci, Paola Chimenti, Cristiano Ferlini, Giovanni Scambia,