| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367955 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the β-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.
Graphical abstractThe purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols, and codrugs of ECA with the β-adrenergic blocking agent atenolol or timolol to overcome the adverse effects of ECA and to enhance its physicochemical properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Grazyna Cynkowska, Tadeusz Cynkowski, Abeer A. Al-Ghananeem, Hong Guo, Paul Ashton, Peter A. Crooks,