| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367956 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.
Graphical abstractImpurity found in commercial tretinoin samples.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gianna Allegrone, Elisabetta Brenna, Giovanni Fronza, Claudio Fuganti, Tommaso Giovenzana, Luciana Malpezzi, Enrico Barlocchi, Cesare Pellegatta,