| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367960 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an α,β-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure–activity study was performed.
Graphical abstractA series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on rats.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Osvaldo J. Donadel, Eduardo Guerreiro, Alejandra O. María, Graciela Wendel, Ricardo D. Enriz, Oscar S. Giordano, Carlos E. Tonn,