Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367967 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
A new biodegradable water-soluble phosphazene trimer–doxorubicin conjugate was synthesized, in which equimolar hydrophilic methoxy-poly(ethylene glycol) with a molecular weight of 350 (MPEG350) and a tumor-specific tetrapeptide (Gly-Phe-Leu-Gly) were grafted to cyclotriphosphazene. The present conjugate exhibited cytotoxicity lower than that of free doxorubicin (IC50 = 0,10 μM) but a reasonably higher in vitro cytotoxicity (IC50 = 1.1 μM) against the leukemia L1210 cell line probably due to its enzymatically controlled release.
Graphical abstractA new biodegradable water-soluble phosphazene trimer–doxorubicin conjugate was synthesized and exhibited lower than free doxorubicin (IC50 = 0.10 μM) but reasonably high in vitro cytotoxicity (IC50 = 1.1 μM) against the leukemia L-210 cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide