Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1367969 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.
Graphical abstractNovel angularly fused pentacyclic heterocycles with coumarin and benzofuran fused to the pyridine ring were synthesized and show promising anti-inflammatory activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Imtyaz A. Khan, Manohar V. Kulkarni, M. Gopal, M.S. Shahabuddin, Chung-Ming Sun,